er stress — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6854	GSK621		Apoptosis , AMPK , Autophagy
	GSK621 is a specific and potent AMPK activator.		Apoptosis , AMPK , Autophagy
T0159	Pranoprofen	Pyranoprofen	Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
	Pranoprofen (Pyranoprofen) (INN) is a non-steroidal anti-inflammatory drug used in ophthalmology.		Apoptosis , COX , PGE Synthase , Prostaglandin Receptor
T1862	PR-619	PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis , DUB , Autophagy
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).		Apoptosis , DUB , Autophagy
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T13867	RH01386		Others
	RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression,has the potential for type 2 diabetes treatment. RH01386 restores ER stress-impaired ...		Others
T6993	Tauroursodeoxycholate sodium	Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,Sodium Tauroursodeoxycholate (TUDC)	Apoptosis , ERK , Caspase
	Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.		Apoptosis , ERK , Caspase
T20797	NE-100 hydrochloride	NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl	Sigma receptor
	NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.		Sigma receptor
T13219	TTA-Q6		Calcium Channel
	TTA-Q6 is a selective T-type Ca2+ channel antagonist with potential antitumor and immunomodulatory activity for the treatment of neurological disorders by inhibiting the uptake of extracellular calcium ions by tumor cell...		Calcium Channel
T29017	TrxR1-IN-B19	TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015	Others
	TrxR1-IN-B19 (TrxR1 IN B19), a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation.		Others
T9110	Ceapin-A7		Others
	Ceapin-A7, with an IC50 of 0.59 μM, selectively inhibits ATF6α signaling in response to ER stress. This compound is instrumental in investigating ATF6α's activation mechanism and its function in pathological conditions.		Others
T8982	RH01687		Others
	RH01687 is a potent β-cell protector , exhibits β-cell-protective activities against endoplasmic reticulum (ER) stress.		Others
T2930	α-Lipoic Acid	Lipoic acid,Alphalipoic acid	NF-κB , HIV Protease , Mitochondrial Metabolism , Endogenous Metabolite
	α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an es...
T5S1285	(+)-(3R,8S)-Falcarindiol	Falcarindiol	Others
	1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a nov...		Others
T40130	Nur77 modulator 1	Nur77 modulator 1	Others
	Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM). Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell ...		Others
T24855	TASIN-1 Hydrochloride	TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl	APC
	TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apopt...		APC
T9564	IRE1α kinase-IN-1		IRE1
	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...		IRE1
T3395	Timosaponin AIII	Filiferin B,AneMarsaponin A3,Timosaponin A3	AChE , mTOR
	Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC...		AChE , mTOR
T8901	YUM70		Apoptosis , GPR , HSP
	YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediate...		Apoptosis , GPR , HSP
T12009	Telomerase-IN-1		Telomerase
	Telomerase-IN-1 is a telomerase inhibitor (IC50: 0.19 μM). telomerase-IN-1 activates hTERT expression through the endoplasmic reticulum stress (ERS) of the ER overreaction (EOR), which then induces ERS, leading to apopto...		Telomerase
T13430	ABTL-0812	α-Hydroxylinoleic acid	Others
	ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.		Others